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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1002/zamm.19720520203

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1720-8386

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Regulation of Superscript86/SuperscriptRbSupe

Authors: A R Carpinelli W J Malaisse
Publish Date: 2014/04/04
Volume: 3, Issue: 4, Pages: 365-370
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Abstract

Antimycin A oligomycin or anoxia augmented 86Rb fractional outflow rate FOR from prelabelled pancreatic islets whether in the absence or presence of glucose This effect could be due to activation of a Ca2+sensitive modality of K+ extrusion being little affected by tetraethylammonium and almost completely suppressed by quinine In the presence of the latter drug antimycin A still provoked a modest increase in 86Rb FOR the magnitude of which was positively related to the extracellular glucose concentration and which could correspond to a discharge of mitochondrial 86Rb It is proposed that the decrease in 86Rb FOR evoked by insulinotropic nutrients eg glucose may depend to a limited extent on an increase in ATP generation rate

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