Authors: L A Gondoni L Vismara P Marzullo R Vettor A Liuzzi G Grugni
Publish Date: 2014/04/09
Volume: 31, Issue: 9, Pages: 765-772
Abstract
Background PraderWilli syndrome PWS is associated with an inappropriate proportion of fat mass FM to nonFM compared to simple obesity Altered body composition in PWS resembles that seen in subjects with GH deficiency in which a reduction of lean body mass LBM is observed The low LBM may contribute to the reduced motor skills seen in PWS patients Aim The objective of the study was to investigate the effects of GH therapy on exercise capacity and body composition in a group of adult subjects with PWS Subjects and methods Twelve PWS adults 7 males and 5 females aged 264±44 yr body mass index 443±46 kg/m2 participated in the study Body composition analysis and exercise stress test were carried out throughout the 12 months GH therapy Body composition was measured by Dual Energy Xray Absorptiometry Physical performance was evaluated using treadmill exercise test Exercise intensity was expressed as metabolic equivalents MET 1 MET= 35 ml O2 kg−1min−1 Statistical analysis was performed by repeatedmeasures analysis of variance followed by posthoc analysis with t test for paired data for comparisons among the different follow ups Results Compared to baseline GH therapy increased LBM at 6 p00001 and 12 months p0005 453±77 kg vs 486±67 kg vs 482±75 kg FM was significantly reduced both after 6 and 12 months p002 561 ±48 vs 537±42 vs 533±48 Attained MET were found to be improved by 16 after 6 months and by 19 after 12 months of GH p0001 while the small further rise between 6 and 12 months was not significant Conclusions Our findings seem to support the view that GH therapy has beneficial effects on physical activity and agility as well as on body composition of adult patients with PWS
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