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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1002/chin.200418079

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1720-8386

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Dermorphin a new opioid peptide stimulates thyro

Authors: Elio Roti E degli Uberti S Salvadori M Bianconi R Emanuele C Rotola G Trasforini G Robuschi R Tomatis A Griudi R Pansini L E Braverman
Publish Date: 2014/04/11
Volume: 7, Issue: 3, Pages: 211-214
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Abstract

The effect of a recently described potent opioid peptide dermorphin DER on TSH secretion in euthyroid subjects has been studied DER infused at a rate of 55 μg/Kg/min for30 min induced a significant increase in serum TSH concentration at 6090 and 120 min after the infusion was begun Treatment with naloxone administered 30 min before the DER infusion with a bolus dose of 4 mg followed by a constant infusion of 1 μ/Kg/min for 150 min prevented the rise in serum TSH Naloxone administered alone did not induce any change in TSH concentration The present findings suggest that DER has a stimulatory effect on TSH secretion probably mediated by opioid receptors These results however do not solve the question as to whether opioids have a physiological role in the control of pituitary TSH secretion

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