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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/bf03013225

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1720-8386

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The effects of calcitonin on idiopathic nephrolith

Authors: P Filipponi C Mannarelli G Gubbiotti A Blass I Moretti S Tini N Giuseppetti S Ballanti P Morucci
Publish Date: 2014/04/09
Volume: 11, Issue: 7, Pages: 509-513
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Abstract

This study was performed to evaluate the antihypercalciuric effect of calcitonin CT a potent inhibitor of bone osteoclastic activity on idiopathic hypercalciuria IH Fortytwo stone formers were studied 18 suffered from fasting hypercalciuria FH 12 from nonfasting hypercalciuria NFH and 12 were normocalciuric stone formers NSF All patients received CT 25 U/day sc for a period of 15 days CT caused a statistically significant drop in urine calcium phosphorus and hydroxyproline OHproline excretion in FH patients and a concomitant increase in serum PTH levels In this group the percentage variation D of urine calcium decrease was linearly correlated with D decrease in urine OHproline These reults support the hypothesis that pathological bone reabsorption might be involved in the genesis of FH

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