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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1002/hep.1840080650

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1720-8386

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Free androgen index and Irisin in polycystic ovary

Authors: H Li X Xu X Wang X Liao L Li G Yang L Gao
Publish Date: 2015/11/19
Volume: 39, Issue: 5, Pages: 549-556
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Abstract

PCOS is associated with hyperandrogenism and insulin resistance IR Recent studies have shown that circulating Irisin levels increase in PCOS women However no report has demonstrated a relationship between Irisin and hyperandrogenism in PCOS women The purpose of the study was to compare interrelationship between Irisin or androgen excess with IR in PCOS and normal subjects166 PCOS and 103 control women were prospectively studied Euglycemic hyperinsulinemic clamps were preformed to assess their insulin sensitivity which was expressed as M value Circulating Irisin was determined by ELISA kit Circulating androgens were measured using ultrasensitive assaysPCOS women with high FAI had significantly higher BMI FAT TC DHEAS and HOMAIR and significantly lower levels of M values and SHBG than PCOS women with low FAI or the controls Pearson correlations showed that in the entire population FAI correlated positively with BMI WHR FAT blood pressure TG DHEAS LH/FSH AUCinsulin HOMAIR and Irisin and negatively with M values In multiple stepwise regression analysis only FAT DHEAS and LH/FSH were independent related factors with FAI

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