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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1016/0029-554x(78)90248-3

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1720-8386

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Involvement of interleukin1 in the inhibition of

Authors: Hiroyuki Shimizu Y Uehara Y Shimomura M Negishi I Kobayashi S Kobayashi
Publish Date: 2014/04/04
Volume: 14, Issue: 5, Pages: 401-404
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Abstract

The effect of recombinant human interleukin1 beta rhlL1b on in vivo insulin secretion was examined in intact and adrenalectomized ADX rats under conscious and pentobarbital anesthetized conditions In conscious rats rhlL1b dosedependently decreased blood glucose levels at 2 h in both groups and significantly inhibited insulin release only at doses of 1 and 10 µg/kg in ADX rats Under pentobarbital anesthesia rhlL1b administration decreased blood glucose levels 2 h later in both intact and ADX rats and resulted in severe hypoglycemia in ADX rats At 2 h later rhlL1b significantly suppressed insulin release by pentobarbital injection in both intact and ADX rats It is concluded that rhlL1b suppresses in vivo insulin secretion in conscious ADX and anesthetized rats

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