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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/s13524-015-0401-6

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1720-8386

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Administration of glutathione in patients with typ

Authors: V Martina G A Bruno E Zumpano C Origlia L Quaranta G P Pescarmona
Publish Date: 2014/03/11
Volume: 24, Issue: 1, Pages: 37-41
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Abstract

Several studies suggest that nitric oxide NO production is impaired in diabetes mellitus Reduced levels of NO could contribute to cardiovascular mortality Furthermore NO synthesis is impaired in glutathione GSHdepleted human umbilical vein endothelial cells and GSH is reduced in patients with type 2 diabetes mellitus T2DM We tested the hypothesis that treatment with GSH may improve platelet constitutive NO sinthase cNOS activity in patients with T2DM Fifteen patients with T2DM underwent a treatment with GSH 600 mg/day im for 10 days With respect to the basal values on the 10th day of treatment the red blood cell GSH concentration and platelets cNOS increased 14±01 vs 19±01 μmol/1010 RBC p0001 and 07±01 vs 29±02 fmol·min−1·10−9 PLTs p0001 respectively and the plasma PAI1 levels diminished 814±37 vs 687±40 ng/ml p0002 A negative correlation between the cNOS and the PAI1 was found on the basal values After a washout of 30 days the values of red blood cell GSH concentration platelet cNOS activity and PAI1 Ag returned to the basal levels These data suggest that the administration of GSH in patients with T2DM is able to improve platelet cNOS activity together with a reduction of PAI1

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