Authors: F Porpiglia C Fiori F C Daffara B Zaggia A Ardito R M Scarpa M Papotti A Berruti G V Scagliotti M Terzolo
Publish Date: 2015/12/22
Volume: 39, Issue: 4, Pages: 465-471
Abstract
We performed a retrospective analysis involving 41 patients with stage II adrenocortical cancer ACC who had undergone radical surgery Patients were divided into two groups according to the surgical procedure group A = radical adrenalectomy alone group AN = radical adrenalectomy + radical nephrectomy Oncologic effectiveness of the procedures was tested comparing the recurrencefree and overall survival of patients of A vs AN groupsThe group A consisted of 25 patients and group AN of 16 patients No differences were noted between the two groups in terms of demographic data and ACC characteristics During followup 15/25 60 patients of group A vs 14/16 875 patients of group AN experienced a recurrence after a median of 36 months in group A and 10 months in group AN p = 006 a significant impairment of renal function was recorded in patients of AN group with respect to those of group A Finally 13/25 52 patients of group A and 10/16 625 patients of group AN died due to ACCrelated causes No differences in survival times were noted p = 03Our study suggests that adjunctive nephrectomy does not modify the oncologic results of adrenalectomy in the treatment of stage II ACC in terms of recurrencefree and overall survival Thus when there are no signs of ACC local invasion surgeon should make every effort to preserve the kidneyAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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