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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1002/jlac.18983000104

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1720-8386

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Expression of hypothalamic corticotropinreleasing

Authors: T Mori Yoshio Murakami M Nishiki K Koshimura H Sasano Y Kato
Publish Date: 2014/03/18
Volume: 26, Issue: 6, Pages: 556-559
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Abstract

A 77yrold man died of metastising adenocarcinoma of the lung He had been treated with hydrocortisone for isolated ACTH deficiency for 9 yr At autopsy the pituitary and the adrenal glands were atrophic Lymphocyte infiltration was not observed in the pituitary the adrenal and the thyroid glands Immunohistochemistry revealed selective loss of ACTHlike immunoreactivity in the pituitary gland whereas CRHimmunoreactive cells were found in the paraventricular nucleus of the hypothalamus This is the first report demonstrating immunohistochemical examinations of the pituitary and the hypothalamus in isolated ACTH deficiency

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