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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/s11639-008-0071-x

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1720-8386

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Human placental ΔSuperscript5/Superscript3βh

Authors: P Scirpa D Mango A Bompiani
Publish Date: 2014/04/05
Volume: 2, Issue: 1, Pages: 83-85
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Abstract

The in vitro effects of dehydroepiandrosterone DHA and allylestrenol on human placental Δ53βhydroxysteroid dehydrogenase Δ45 isomerase activity Δ53βHSDH was investigated by incubation of subcellular fractions with 414C pregnenolone It has been found that DHA inhibits the Δ53βHSDH activity up to −81 at 5×10−5M concentration while allylestrenol seems to be able to lightly stimulate the Δ53βHSDH activity with a maximum effect +15–26 at 5×10−7M concentration The data concerning allylestrenol seem of particular interest as this compound is used as a progestative drug during pregnancy if one consider the inhibitory effect exerted by several natural and synthetic steroids on the Δ53βHSDH activity

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