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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/bf00601265

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1720-8386

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Effect of bromocriptine administration on gastric

Authors: R Caldara C Ferrari M Romussi A Paracchi
Publish Date: 2014/04/05
Volume: 2, Issue: 1, Pages: 45-49
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Abstract

The effects of acute oral administration of the dopaminergic drug bromocriptine 5 mg on basal and submaximal 1 and 3 μg per kg bw given sc and maximal 6 μg per kg bw pentagastrinstimulated gastric acid secretion and on basal and mealinduced gastrin release have been evaluated in healthy volunteers Although basal and maximal pentagastrinstimulated acid output did not change the response to submaximal pentagastrin doses was significantly increased Basal and stimulated serum gastrin concentrations were not modified nor was fasting serum gastrin during chronic bromocriptine treatment 10 mg per day for 90 days in acromegalic patients As dopamine infusion is known to reduce basal and pentagastrininduced gastric acid secretion the presently reported effect of bromocriptine is not dependent on dopamine receptor stimulation It is suggested that it might be due to αadrenergic and/or serotoninergic antagonism both actions being properties of bromocriptine Alternatively since bromocriptine at variance with iv infused dopamine crosses the bloodbrain barrier the effect of this drug on gastric function might depend on interference by centrally mediated actions on those directly exerted at the gastric level

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