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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/s00015-011-0069-x

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1720-8386

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Effect of chronic bromocriptine administration on

Authors: G Verde G Oppizzi P G Chiodini D Dallabonzana G Luccarelli A Liuzzi
Publish Date: 2014/04/11
Volume: 8, Issue: 2, Pages: 113-115
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Abstract

The effect of chronic bromocriptine administration 75–20 mg/day for 1 32 months on the size of “nonsecreting” pituitary adenomas NPA was studied in 20 patients Brain computed tomography showed a marked reduction of the adenoma in one patient after 1 month of treatment 75 mg/day further scans taken 2 and 15 months later under the same bromocriptine dose did not show any other variations in the tumoral mass In the remaining 19 patients no changes in tumor size were documented by CT during the treatment Four patients had a worsening of visual fields during bromocriptine administration and they were referred for neurosurgery In conclusion bromocriptine was ineffective in reducing tumor size in all but one patient with NPA and in some cases it did not prevent tumor growth as is suggested by the worsening of visual fields Thus bromocriptine treatment at least at the doses capable of shrinking macroprolactinomas seems to be of limited value in patients with NPA

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