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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1007/bf02858555

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1720-8386

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BRAF mutation analysis in thyroid nodules with ind

Authors: P Agretti F Niccolai T Rago G De Marco A Molinaro M Scutari C Di Cosmo G Di Coscio M Vitale M Maccheroni P Vitti M Tonacchera
Publish Date: 2014/09/07
Volume: 37, Issue: 10, Pages: 1009-1014
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Abstract

Fineneedle aspiration FNA with cytologic evaluation is the most reliable tool for malignancy prediction in thyroid nodules but cytologic diagnosis remains indeterminate for 12–18  of nodules BRAF V600E mutation has been reported to show a high specificity for malignant thyroid nodules and the use of this marker to refine indeterminate FNA cytology results may be a useful diagnostic adjunctive tool in the preoperative evaluation of thyroid nodules The aim of this study was to estimate the prevalence of BRAF exon 15 mutation V600E and its clinical value as a diagnostic tool in a series of thyroid nodules with indeterminate cytology from an area of borderline iodine deficiencyOne hundred and fiftythree thyroid samples obtained by FNA of thyroid nodules from 151 patients were subjected to the analysis of BRAF V600E mutation by direct sequencing In the study 54 nodules with indeterminate cytology 56 benign and 43 malignant thyroid nodules were included

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