Authors: B Meczekalski A Czyzyk M Kunicki A PodfigurnaStopa L Plociennik G Jakiel M MaciejewskaJeske K Lukaszuk
Publish Date: 2016/06/14
Volume: 39, Issue: 11, Pages: 1259-1265
Abstract
Fertility is referred to the capability for having offspring and can be evaluated by fertility rate Women’s fertility is strictly dependent on individual’s age The fertility peak occurs in the early 20s and it starts to decline in the third and fourth decades of life falling sharply after age 35There are a lot of factors responsible for decrease of fertility in women of late reproductive age These factors can be classified as oocytedependent decrease in oocyte quantity and quality and oocyteindependent reproductive organs uterus oviducts status and general health AntiMüllerian hormone AMH is a dimeric glycoprotein of the transforming growth factorβ TGFβ superfamily produced directly by the ovarian granulosa cells of secondary preantral and early antral follicles It has been used as an ovarian reserve marker since 2002 AntiMüllerian hormone seems to be the best endocrine marker for assessing the agerelated decline of the ovarian pool in healthy women Evaluation of AMH’s predictive value in the naturally aging population is important for counseling women about reproductive planning as well as for treatment planning for women experiencing hormonesensitive gynecological conditions such as endometriosis and fibroidsFertility can be defined as natural capability for having offspring and measured using fertility rate ie the number of live births per 1000 women In demographic or socioeconomic context fertility is measured using total fertility rate index which is a the total number of children per women during her whole life 1 It is well known that women’s fertility is strictly dependent on individual’s age and that fertility peak occurs in the early 20s and it starts to decline in the third and fourth decades of life falling sharply after age 35 2 Menopause is understood as a natural cessation of women’s reproductive ability It typically occurs in women in late 40s and early 50s 3 Therefore conceiving a baby by women between older than 35 years old can be regarded as fertility in late reproductive age It has been estimated that at age 35 and 40 66 and 44 women respectively will have a conception ending in live birth within 1 year 4
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