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Title of Journal: J Endocrinol Invest

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Abbravation: Journal of Endocrinological Investigation

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Springer International Publishing

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DOI

10.1016/0360-8352(91)90141-r

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1720-8386

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Proteomic analysis of human thyroid fine needle as

Authors: L Giusti P Iacconi F Ciregia G Giannaccini F Basolo G Donatini P Miccoli A Lucacchini
Publish Date: 2014/04/09
Volume: 30, Issue: 10, Pages: 865-869
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Abstract

The aim of this study was to determine the protein pattern of human thyroid fine needle aspiration fluid FNA using a proteomic approach FNA proteins were separated using 2dimensional gel electrophoresis 2DE digested and then analyzed by peptide mass fingerprinting For the first time we provided an image of the protein components of the FNA in which approximately 220 protein spots can be identified The proteome analysis revealed a specific fingerprint of FNA with proteins appertaining to various functional systems Our preliminary results of FNA protein pattern could be a starting point in studying the presence of potential markers implicated in thyroid diseases

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