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Title of Journal: Breast Cancer

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Abbravation: Breast Cancer

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Springer Japan

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ISSN

1880-4233

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Predictive value of FDG PET/CT for pathologic axil

Authors: Bhumsuk Keam SeockAh Im Youngil Koh SaeWon Han DoYoun Oh Nariya Cho Jee Hyun Kim Wonshik Han Keon Wook Kang Woo Kyung Moon TaeYou Kim In Ae Park DongYoung Noh JuneKey Chung YungJue Bang
Publish Date: 2012/02/07
Volume: 20, Issue: 2, Pages: 167-173
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Abstract

Seventyseven stage II or III breast cancer patients who received 3 cycles of neoadjuvant docetaxel/doxorubicin chemotherapy were enrolled in this prospective study FDG PET/CTs were acquired before chemotherapy and after the first cycle of chemotherapy for early metabolic response predictionPatients with pN0 had significantly lower postNAC ALN standard uptake value SUV than those who were pN+ 122 ± 146 in pN0 vs 213 ± 199 in pN+ P = 0017 PostNAC ALN size on CT also differed according to pathologic ALN status 63 mm in pN0 vs 111 mm in pN+ P = 0014 When serial FDG PET/CT and chest CT were used patients with an SUV  15 and postNAC ALN size ≥10 mm on CT did not achieve pN0 specificity 100 and positive predictive value 100The serial FDG PET/CT after NAC could predict the pathologic status of ALN before surgery in stage II/III breast cancer Our findings suggest that the combined use of serial FDG PET/CTs and chest CT might provide better information regarding ALN before surgeryThis research was supported by grants from the Priority Research Centers Program through the National Research Foundation of Korea NRF funded by the Ministry of Education Science and Technology 20090093820 and the Seoul National University Hospital research fund 0320100190

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