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Title of Journal: Breast Cancer

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Abbravation: Breast Cancer

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Springer Japan

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DOI

10.1002/chin.201434026

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ISSN

1880-4233

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Oncologic outcomes and technical considerations of

Authors: Ayaka Shimo Koichiro Tsugawa Seiko Tsuchiya Reiko Yoshie Kyoko Tsuchiya Tomoko Uejima Yasuyuki Kojima Arata Shimo Ryosuke Hayami Toru Nishikawa Yukari Yabuki Hisanori Kawamoto Akihiko Sudo Mamoru Fukuda Yoshihide Kanemaki Ichiro Maeda
Publish Date: 2015/10/13
Volume: 23, Issue: 6, Pages: 851-860
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Abstract

We evaluated the oncological outcome of 425 breasts in 413 patients who underwent NSM between January 2000 and March 2013 We retrospectively reviewed patient data and analyzed all patient characteristics as potential risk factors of recurrence at the nipple–areola complex NAC To confirm the oncological safety of NSM we compared outcomes of NSM and conventional total mastectomyThe median followup time after surgery was 468 months range 6–158 months Nipple necrosis was observed in 6 cases 14  The cumulative local recurrence rate after NSM was 58  25/425 cases similar to that of conventional total mastectomy in the same period 56  49/878 cases Furthermore the cumulative local recurrence rate at the NAC was 23  10 cases HER2enriched tumors and young age 40 years were significant risk factors for recurrence at the NAC In patients with recurrence the site of recurrence was easily excised and good cosmetic results were achieved in breast reconstruction casesNSM is safe with a low complication rate No significant difference was observed in cumulative local recurrence rate cumulative distant disease recurrence rate and overall survival between patients who underwent NSM or conventional total mastectomy confirming that NSM was surgically and oncologically safe

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