Authors: Katsuya Suemaru Hiroaki Araki Yoshihisa Kitamura Kayo Yasuda Yutaka Gomita
Publish Date: 2001/09/11
Volume: 159, Issue: 1, Pages: 38-41
Abstract
Rationale The involvement of central serotonergic systems has been hypothesized clinically to contribute to nicotine withdrawal symptoms However involvement of the serotonin2 5HT2 receptor system in nicotine withdrawal is not clear Objectives The changes in wetdog shake responses induced by ±125dimethoxy4iodophenyl2aminopropane DOI a selective 5HT2 receptor agonist following nicotine cessation was investigated in rats Methods DOI 1 mg/kg SC was administered 24 h after the final treatment of saline or nicotine 05 mg/kg per day SC for 7 or 21 days Results Cessation of nicotine administration for 7 or 21 days increased DOIinduced wetdog shake responses A single administration of nicotine 05 mg/kg SC had no effect on DOIinduced wetdog shakes The enhancement by the cessation of nicotine treatment for 7 days was abolished by coadministration of nicotine Mecamylamine 3 mg/kg IP a nicotinic receptor antagonist precipitated DOIinduced wetdog shake responses in rats chronically treated with nicotine but not with saline Conclusions These findings suggest that cessation of chronic nicotine produced increased sensitivity to 5HT2 receptor systems and that the 5HT2 receptor systems may be involved in the nicotine withdrawal symptoms
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