Monoamine transporter gene polymorphisms affect su

Authors: Wenjiao Min Tao Li Xiaohong Ma Zhengyu Li Tao Yu Dong Gao Bo Zhang Yang Yun Xueli Sun

Publish Date: 2009/05/26

Volume: 205, Issue: 3, Pages: 409-417

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Abstract

Serotonin transporter 5HTT and norepinephrine transporter NET are the primary targets of many antidepressants We aimed to determine the potential correlations of 5HTT/NET gene polymorphisms with the susceptibility to depression and the antidepressant response to selective serotonin reuptake inhibitors SSRIs or dual selective serotonin/norepinephrine reuptake inhibitors SNRIsA total of 579 depressed patients and 437 healthy controls all of Chinese Han region were collected and genotyped by polymerase chain reactions PCR All patients were under treatment of SSRI or SNRI for 6 weeks and were evaluated using a 17item Hamilton Depression Rating Scale HAMDFive hundred sixtyseven of 579 patients completed the total treatment of which 362 were in SSRI and 205 in SNRI group It was shown that the NETT182C interacting with 5HTTLPR was associated with the susceptibility to depression Patients with both NETT182C C/C and 5HTTLPR S/S genotypes had lower baseline HAMD scores Patients with 5HTTLPR L/L or STin2 12/12 genotype experienced better clinical response to the SSRI treatment Besides the STin2 12/12 carriers showed a superior reduction to HAMD scores over treatment period No correlation between NET T182C/G1287A polymorphisms and antidepressant response was observedOur study revealed a positive association of the NETT182C polymorphism with susceptibility to and severity of depression and a positive association between the 5HTT polymorphisms and the antidepressant response to SSRI Combinations of these polymorphisms provided some potential gene–gene interaction effects These findings might be of some clinical values in optimization of depression treatmentHAMD scores during the course of SNRI treatment in three a 5HTTLPR b STin2 c NETT182C and d NETG1287A groups All data analyses were performed using repeatedmeasures ANOVA No significant difference was found among the three groups in a F = 1190 df = 2 p = 0306 b F = 0799 df = 1 p = 0372 c F = 0899 df = 2 p = 0409 d F = 0125 df = 2 p = 0833 GIF 51 kb

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