Authors: Yu Ohmura Iku TsutsuiKimura Haruko Kumamoto Masabumi Minami Takeshi Izumi Taku Yamaguchi Takayuki Yoshida Mitsuhiro Yoshioka
Publish Date: 2011/09/21
Volume: 219, Issue: 2, Pages: 421-432
Abstract
Following training for the 3CSRTT rats were acutely administered lithium chloride LiCl 0 32 10 and 32 mg/kg ip valproic acid 0 10 32 and 100 mg/kg ip or carbamazepine 0 10 20 and 30 mg/kg ip To assess the anorexic effects of lithium a simple food consumption test was conductedLiCl dosedependently decreased the number of premature responses an index of impulsivelike action A high dose of LiCl 32 mg/kg decreased food consumption but its anorexic effects were not correlated with the effects of LiCl on premature responses A moderate dose of LiCl 20 mg/kg significantly reduced the number of premature responses without affecting motivationrelated measures in the 3CSRTT or the amount of food consumption Although carbamazepine prolonged reward latency an index of motivation for food neither valproic acid nor carbamazepine significantly affected premature responsesIt is likely that lithium has a suppressive effect on impulsive action independent of the anorexic effect Lithium may suppress impulsive behavior and thereby decrease the risk of suicide The present results could provide an explanation for the antisuicidal effects of lithium and suggest that lithium could be a beneficial treatment for impulsivityrelated disorders
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