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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer-Verlag

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DOI

10.1007/s13394-012-0034-7

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1432-2072

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Social defeat increases alcohol preference of C57B

Authors: A P Croft S P Brooks J Cole H J Little
Publish Date: 2005/10/05
Volume: 183, Issue: 2, Pages: 163-
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Abstract

Alcohol preference in a twobottle choice 8 v/v alcohol or water was measured in separate experiments after either a single experience of social defeat by a resident male mouse five consecutive daily defeat experiences or one experience per week for 4 weeks Comparison was made with effects of repeated social defeat on the preference for dilute sucrose In addition the actions of the CCKB receptor antagonist CAM1028 and of diazepam were examined on the effects of repeated defeat experiencesFive consecutive daily defeat experiences had a slow onset effect in increasing alcohol preference and consumption compared with five daily exposures to a novel environment A single defeat or one defeat per week did not significantly alter alcohol preference or intake There were no effects of five daily defeat experiences on sucrose preference or consumption The effect of repeated defeats on alcohol preference was significantly decreased by administration of the CCKB receptor antagonist CAM1028 prior to each experience but not by corresponding administration of diazepam

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