Authors: Masoumeh Nozari Farshad Alizadeh Mansouri Mohammad Shabani Hojat Nozari Nafiseh Atapour
Publish Date: 2015/03/07
Volume: 232, Issue: 14, Pages: 2541-2550
Abstract
Female Wistar rats were injected with MK801 1 mg/kg from postnatal days P 6–10 Task acquisition working memory error WME and reference memory error RME were assessed in an eightarm radial maze task Behavioral performance of rats was also tested in an open field test before P35–P40 and after P65–P70 radial maze training to assess anxiety and locomotion EE was applied from birth up to the end of experimentsMK801 treatment did not influence task acquisition in the radial maze however by the end of training MK801treated rats made significantly more WME but not RME compared to control rats Ratio of WME to total error was also significantly higher in MK801 group EE prevented MK801associated behaviors in the open field but did not exert beneficial effects on working memory deficit in the radial maze task EE per se affected behavioral performance of rats only in the open field testOur results suggest that postnatal MK801 treatment differentially affects working and reference memory in a young brain Anxiety and hyperactivity associated with MK801 are observed more severely in adulthood Dissociation of the positive effects of EE may suggest selective modification of distinct pathways
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