Authors: Celia J A Morgan Edward B Perry HyungSang Cho John H Krystal Deepak Cyril D’Souza
Publish Date: 2006/08/01
Volume: 187, Issue: 4, Pages: 405-414
Abstract
Behavioral data including positive and negative symptoms Brief Psychiatric Rating Scale perceptual alterations ClinicianAdministered Dissociative States Scale CADSS and “high” and “anxiety” states Visual Analog Scale from 295 subjects who participated in a total of 11 placebocontrolled ketamine studies were analyzed In a subset of subjects memory Hopkins Verbal Learning Task HVLT n=108 and attention continuous performance task n=177 data were also analyzedMale participants showed a greater performance decrement on the HVLT after ketamine administration compared to women Men also reported a greater subjective sense of memory impairment on a CADSS subscale No other gender differences in behavioral or cognitive measures were observedMen showed a greater vulnerability to the amnestic effects of ketamine than women Possible explanations of these findings are neuroanatomical and cognitive differences in processing of words in men and women and interactions between sex hormones and NMDAR functionThe authors wish to acknowledge the critical contributions to this research program made by the research staff of the Biological Studies Unit West Haven VA Medical Center including Elizabeth O’Donell RN Angelina Genovese RN Sonah Yoo RPh and Robert Sturwold RPh The authors acknowledge support from the 1 Department of Veterans Affairs Schizophrenia Biological Research Center Alcohol Research Center National Center for PTSD and Merit Review Program to JK 2 National Institute of Alcohol Abuse and Alcoholism KO2 AA 0026104 to JK 3 National Institute of Mental Health RO1 MH6101902 to DCD P50 MH4486615 to JK 4 National Institute of Drug Abuse 1 DA1238201 to DCD 5 Stanley Foundation to DCD 6 Bogue Fellowship from University College London to CJAM and 7 National Alliance for Research in Schizophrenia and Depression NARSAD Young Investigator Award to HSC and EBP
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