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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer Berlin Heidelberg

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1432-2072

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Brain DNA damage and behavioral changes after repe

Authors: Priscila A Costa Jefferson H Z Poli Nathalia D M Sperotto Dinara J Moura Jenifer Saffi Maurício S Nin Helena M T Barros
Publish Date: 2015/08/02
Volume: 232, Issue: 19, Pages: 3623-3636
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Abstract

Male Wistar rats were subjected to an oral ethanol selfadministration procedure with a forced diet where they were offered 8  v/v ethanol solution for 21 days followed by five repeated 24h cycles alternating between ethanol withdrawal and reexposure Control animals received an isocaloric control diet without ethanol Behavioral changes were analyzed on ethanol withdrawal days in the openfield OF and elevated plusmaze EPM tests within the first 6 h of ethanol deprivation The prefrontal cortex hypothalamus striatum hippocampus and cerebellum were dissected for alkaline and neutral comet assays and for dichlorofluorescein ROS testingThe repeated intermittent ethanol access enhanced solution intake and alcoholseeking behavior Decreased exploratory activity was observed in the OF test and the animals stretched less in the EPM test DNA singlestrand breaks and ROS production were significantly higher in all structures evaluated in the ethanoltreated rats compared with controlsThe animal model of repeated intermittent ethanol access induced behavioral changes in rats and this ethanol exposure model induced an increase in DNA singlestrand breaks and ROS production in all brain areas Our results suggest that these brain damages may influence future behaviorsThe authors are thankful to the following graduate students Caletti G Umpierrez LS Freese L and Souza MF and to the technicians Letícia Maya and Mário Serapião for their technical assistance We thank the CNPq HMTB1C for support and the CAPES/REUNI Costa PA for fellowship funding

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