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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer-Verlag

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DOI

10.1007/bf02851527

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1432-2072

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Hippocampal function in cognition

Authors: J David Sweatt
Publish Date: 2004/03/02
Volume: 174, Issue: 1, Pages: 99-110
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Abstract

Any consideration of cognitive disruption in schizophrenia quite naturally leads to questions concerning the cellular and molecular mechanisms underlying normal cognition This review will describe emerging models for the cellular basis of cognitive processing in the hippocampusThis review will describe results from several laboratories that have used in vivo recording in behaving rodents to probe the role of the hippocampus in cognition These exciting studies have indicated a broader role of the hippocampus in general information processing than was previously appreciated These recent results suggest that the hippocampus is involved in minutetominute cognitive processing including spatial information processing temporal sequencing and formulating the relationships between objects in the environmentThe hippocampus appears to play a major role in bringing together environmental signals and producing a cohesive and unified percept in the spatial and temporal domains This new view of the role of the hippocampus in cognition fits strikingly well with models for schizophrenia hypothesizing hippocampal dysfunction as one cause of cognitive decline in schizophrenic patients

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