Authors: Suzanne Higgs Alison J Cooper Nicholas M Barnes
Publish Date: 2010/12/08
Volume: 214, Issue: 4, Pages: 941-947
Abstract
Microstructural analyses of licking for a glucose solution by nondeprived male rats were performed over a range of doses of sibutramine to identify a selective satietyenhancing dose experiment 1 Similar analyses were performed after administration of a vehicle control two doses of SB 242084 alone or two doses of SB 242084 in combination with sibutramine experiment 2Sibutramine at doses of 1–3 mg/kg selectively reduced glucose consumption via a reduction in the number of bouts of licking Nonselective effects to increase latency to lick were only observed at the higher dose of 6 mg/kg Coadministration of sibutramine 3 mg/kg with SB 242084 1 or 3 mg/kg reversed the effect of sibutramine on bout number whereas either dose of SB 242084 alone had no significant effectWe confirm behaviourally selective effects of sibutramine on feeding and provide further support for the satietyenhancing effects of sibutramine Our data also provide evidence for the involvement of the 5HT2C receptor in the satietyenhancing effects of sibutramine although additional targets may have an impact and further investigation of the molecular mechanisms underlying the efficacy of sibutramine as an anorectic is warranted
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