Authors: Marie Cahir Tara Ardis Gavin P Reynolds Stephen J Cooper
Publish Date: 2006/11/24
Volume: 190, Issue: 4, Pages: 497-506
Abstract
Freeplasma TRP central TRP and central 5HT levels were significantly and similarly reduced by ATD and 1 and 3week CTD compared to controls ATD significantly reduced 5HT1A binding in the dorsal raphe 14 but did not significantly alter postsynaptic 5HT1A binding frontal cortex remaining cortex and hippocampus or 5HT2A binding cortex and striatum Oneweek CTD did not significantly alter cortical 5HT2A binding or postsynaptic 5HT1A binding Furthermore 3week CTD did not significantly alter 5HT1A binding but significantly increased cortical 5HT2A binding without affecting striatal or hippocampal levels In the CTD 1 and 3week groups rat body weight was significantly decreased as compared to controls However weight loss was not a confounding factor for decreased cortical 5HT2Areceptor bindingATDinduced reduction in somatodendritic 5HT1A autoreceptor binding may represent an intrinsic ‘homeostatic response’ reducing serotonergic feedback in dorsal raphe projection areas In contrast the increase in 5HT2A receptor after CTD may be a compensatory response to a longterm reduction in 5HTThis research was supported by a grant from the Research and Development Office of the Department of Health Social Services and Public Safety in Northern Ireland All experiments contained within this manuscript comply with the current laws of the UK We thank Dr C Kelly for helpful comments regarding the manuscript
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