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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer-Verlag

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DOI

10.1002/mgr.30239

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1432-2072

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Reinforcing and subjective effects of methylphenid

Authors: Scott H Kollins Joseph English Rachel Robinson Matt Hallyburton Allan K Chrisman
Publish Date: 2008/12/23
Volume: 204, Issue: 1, Pages: 73-
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Abstract

Following screening 33 adults n = 16 with ADHD n = 17 free from psychiatric diagnoses completed four pairs of experimental sessions each of which included a sampling session and a selfadministration session During sampling sessions subjects received in randomized order 0 placebo 20 40 and 60 mg MPH During selfadministration sessions subjects completed a progressive ratio PR task to earn portions of the dose received on the corresponding sampling session Subjective effects were recorded throughout all sessions The main outcome measure for the study was the number of ratios completed on the PR task Secondary measures included peak subjective effects and areaunderthecurve values for subjective effectsCompared to the control group the ADHD group completed more ratios on the PR task Both groups showed robust effects of methylphenidate on subjective endpoints Main effects of group were noted on subjective effects involving concentration and arousal

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