Authors: Dou Yin YuanYuan Liu TianXiao Wang ZhenZhen Hu WeiMin Qu JiangFan Chen NengNeng Cheng ZhiLi Huang
Publish Date: 2015/10/29
Volume: 233, Issue: 2, Pages: 281-293
Abstract
The data revealed that paeoniflorin 50 or 100 mg/kg ip significantly increased the mechanical threshold and prolonged the thermal latency in partial sciatic nerve ligation PSNL mice Meanwhile paeoniflorin increased nonrapid eye movement NREM sleep amount and concomitantly decreased wakefulness time However pretreatment with l3dimethy8cyclopenthylxanthine an adenosine A1 receptor R A1R antagonist abolished the analgesic and hypnotic effects of paeoniflorin Moreover paeoniflorin at 100 mg/kg failed to change mechanical threshold and thermal latency and NREM sleep in A1R knockout PSNL mice Immunohistochemical study showed that paeoniflorin inhibited cFos overexpression induced by PSNL in the anterior cingulate cortex and ventrolateral periaqueductal grayThis study was supported in part by grantsinaid for scientific research from the National Basic Research Program of China 2011CB711000 2015CB856401 2009ZX09303006 the National Natural Science Foundation of China 81420108015 81301135 31171010 31171049 31121061 31271164 J1210041 31471064 a key laboratory program of the Education Commission of Shanghai Municipality ZDSYS14005 the Shanghai Committee of Science and Technology 13ZR1403200 14JC1400900 13dz2260700 13140903100 and the Shanghai Leading Academic Discipline Project B119
Keywords: