Authors: Mark J Millan Sylvie Veiga Sylvie Girardon Mauricette Brocco
Publish Date: 2003/04/30
Volume: 168, Issue: 4, Pages: 397-409
Abstract
Though 5HT plays an important role in the modulation of motor function which is perturbed in depressive states little is known concerning the influence of serotonin reuptake inhibitors SSRIs on locomotor activity LA Recently we demonstrated that SSRIs such as citalopram enhance LA in mice exposed to a novel environmentCitalopraminduced LA was dosedependently attenuated by the 5HT1B/1D receptor antagonists S18127 GR125743 and GR127935 and by the selective 5HT1B antagonist SB224289 but unaffected by the selective 5HT1A antagonist WAY100635 The selective antagonists at 5HT2A receptors MDL100907 and SR46349 also dosedependently attenuated induction of locomotion by citalopram whereas the 5HT2B antagonist SB204741 and the 5HT2B/2C antagonist SB206553 were ineffective Further the selective 5HT2C antagonist SB242084 potentiated the response to citalopram Selective antagonists at 5HT3 ondansetron 5HT4 GR125487 5HT6 SB271046 and 5HT7 SB269970 receptors did not significantly modify the action of citalopram Underpinning these findings SB224289 GR125743 MDL100907 and SR46349 likewise attenuated induction of locomotion by a further SSRI fluvoxamineThe locomotor response to SSRIs of mice exposed to a novel environment is mediated via 5HT1B and 5HT2A receptors In view of the importance of motor function to the etiology and treatment of depression the significance of these observations to the clinical actions of SSRIs will be of interest to elucidate
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