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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer-Verlag

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DOI

10.1016/0378-4347(91)80588-4

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1432-2072

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Medicationrelated pharmacological manipulations o

Authors: Kathleen M Coen K Laurel Adamson William A Corrigall
Publish Date: 2008/09/16
Volume: 201, Issue: 4, Pages: 557-568
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Abstract

The objective of the study was to evaluate the response of nicotine selfadministration NSA to pharmacological agents related to the smoking cessation medication bupropion and to nicotine dosing mimicking nicotine replacement on fixedratio FR and progressiveratio PR schedules of reinforcementNSA was maintained at a nicotine dose of 30 μg/kg/infusion iv in rats trained on FR5 and PR40 schedules Pharmacological manipulations related to bupropion were examined by treating animals with a dopamine reuptake inhibitor GBR 12909 GBR a norepinephrine reuptake inhibitor nisoxetine NIS and a nicotinic antagonist dihydroβerythroidine DHβE The effect of nicotine replacement was examined on the PR schedule by chronic dosing with osmotic minipumpsNoradrenergic–nicotinic cholinergic interactions and enhanced responding consequent to dopamine reuptake inhibition may be part of the complex behavioral pharmacology of bupropionlike compounds Observation of differential results with the two schedules has implication for the use of selfadministration techniques to elaborate the mechanisms of dependence as well as drug discovery

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