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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer Berlin Heidelberg

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DOI

10.1007/978-1-4939-6649-3

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1432-2072

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Etazolate a phosphodiesterase4 enzyme inhibitor

Authors: Ankur Jindal Radhakrishnan Mahesh Shvetank Bhatt
Publish Date: 2014/08/15
Volume: 232, Issue: 3, Pages: 623-637
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Abstract

Olfactory bulbectomy OBX is a widely used model for antidepressant screening and known to induce neurodegeneration in several brain areas Our earlier studies demonstrated that etazolate produced antidepressantlike effects in behavioral despair models of depression however the potential role of etazolate on behavior and morphological changes in the hippocampus region along with its underlying mechanisms following OBX has not been adequately addressedThe effects of etazolate were measured in a battery of behavioral paradigms including the forced swim test FST sucrose consumption open arm activity in elevated plus maze EPM and hyperemotionality tests The underlying mechanisms were investigated by measuring serum corticosterone CORT cyclic adenosine monophosphate cAMP cAMP response element binding protein CREB brainderived neurotrophic factor BDNF and oxidative/nitrosative stress lipid peroxidation and nitrite levels and antioxidant enzymes like reduced glutathione GSH superoxide dismutase SOD and catalase CAT levels in the hippocampusOBX rats showed depressionlike behavior anomalies in behavioral paradigms OBX rats also showed high CORT and decreased cAMP phosphorylated CREB pCREB and BDNF levels Additionally we found increased oxidative/nitrosative stress and reduced antioxidant enzyme levels in the hippocampus Histopathological analysis showed morphological changes and neuronal loss in the hippocampus Etazolate 05 and 1 mg/kg attenuated the OBXinduced behavioral biochemical neurobiological and histopathological alterations

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