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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer-Verlag

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DOI

10.1007/s11661-998-0275-y

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1432-2072

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Apomorphineinduced disruption of prepulse inhibit

Authors: H Russig W Spooren S Durkin J Feldon B K Yee
Publish Date: 2004/02/25
Volume: 175, Issue: 2, Pages: 143-147
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Abstract

Prepulse inhibition PPI of startle refers to the phenomenon in which a weak prepulse attenuates the startle response to a succeeding intense stimulus PPI can be disrupted by systemic apomorphine in animals and reduced PPI has been consistently reported in schizophrenia patients The ability of the atypical antipsychotic clozapine to reverse apomorphineinduced PPI deficit has been demonstrated in the rat but has not yet been tested in the mouse The present study was designed to fill this gapWe investigated the efficacy of clozapine in reversing apomorphineinduced 20 or 25 mg/kg SC PPI deficit in C57BL6 mice Clozapine failed to restore PPI disruption in apomorphinetreated mice in two independent laboratories across two dose ranges 1–3 mg/kg IP or 3–30 mg/kg PO whereas the typical antipsychotic haloperidol 1 mg/kgIP completely normalised PPI performanceUnlike the rat apomorphineinduced PPI disruption in mice might be instrumental in distinguishing between typical and atypical antipsychotic drugs This also lends further support to the suggestion that the neuropharmacology of PPI is not identical in the two rodent species

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