Authors: Evellyn Claudia Wietzikoski Suelen Lúcio Boschen Edmar Miyoshi Mariza Bortolanza Lucélia Mendes dos Santos Michael Frank Marcus Lira Brandão Philip Winn Claudio Da Cunha
Publish Date: 2011/07/01
Volume: 219, Issue: 1, Pages: 159-169
Abstract
Adult male Wistar rats received intraperitoneal ip intraNAc or intraDLS injections of the D1 dopamine receptor agonist SKF 81297 or the D1 receptor antagonist SCH 23390 20 min before or immediately after a training session in the CAR task twoway active avoidance carried out 24 h before a test sessionPretraining administration of SCH 23390 but not SKF 81297 caused a significant decrease in the number of CARs in the test but not in the training session when injected into the DLS or in either session when injected into the NAc It also caused a significant increase in the number of escape failures in the training session when injected into the NAc Systemic administration caused a combination of these effects Posttraining administrations of these drugs caused no significant effect
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