Authors: Ivo Emílio da Cruz Jung Alencar Kolinski Machado Ivana Beatrice Mânica da Cruz Fernanda Barbisan Verônica Farina Azzolin Thiago Duarte Marta Maria Medeiros Frescura Duarte Pedro Antônio Schmidt do PradoLima Guilherme Vargas Bochi Gustavo Scola Rafael Noal Moresco
Publish Date: 2015/09/21
Volume: 233, Issue: 9, Pages: 1715-1723
Abstract
Antipsychotic drugs such as haloperidol and risperidone are used in longterm treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions Available evidence suggests that these drugs have proinflammatory effect which contributes to the establishment of endocrine disturbances However results yielded by extant studies are inconsistent Therefore in this work we tested the in vitro effects of different high concentrations of haloperidol and risperidone on the activation of isolated macrophages RAW 2647 cell line The results indicated that macrophages were activated by both drugs In addition the activation involved an increase in nitric oxide levels and apoptosis events by modulation of caspases 8 and 3 levels and a decrease of the Bcl2/BAX gene expression ratio Cells treated with haloperidol and risperidone also presented higher concentrations of inflammatory cytokines IL1β IL6 TNFα and low levels of IL6 antiinflammatory cytokine in a dosedependent manner Despite the limitation of cell line studies based solely on macrophages cells we suggest that antipsychotic drugs could potentially exacerbate inflammatory processes in peripheral tissues blood and fat The continued activation of macrophages could contribute to the development of obesity and other endocrine disturbances caused by the use of antipsychotic drugs
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