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Title of Journal: Psychopharmacology

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Abbravation: Psychopharmacology

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Springer-Verlag

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DOI

10.1016/j.amjcard.2009.12.069

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1432-2072

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Delayed preattentional functioning in early psycho

Authors: Nicole Pesa Daniel F Hermens Robert A Battisti Manreena Kaur Ian B Hickie Nadia Solowij
Publish Date: 2012/03/09
Volume: 222, Issue: 3, Pages: 507-518
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Abstract

Cannabis use is prevalent among the early psychosis EP population The eventrelated potentials mismatch negativity MMN and P3a are reduced in EP Cannabinoids have been shown to modulate NmethylDaspartate receptors which are involved in MMN generationEP was defined as a history of psychosis or psychotic symptoms with no progression to date to chronic schizophrenia Twentytwo EP patients with cannabis use EP + CANN 22 noncannabisusing EP patients EPCANN and 21 healthy controls participated in this study MMN/P3a was elicited using a twotone auditory paradigm with 8 duration deviantsAs expected EPCANN showed marked reductions in MMN/P3a amplitudes compared to controls However EP + CANN showed evidence of a different pattern of neurophysiological expression of MMN/P3a compared to nonusing patients most notably in terms of delayed frontal MMN/P3a latenciesThe authors are grateful to Patricia Michie and Juanita Todd for their advice early in the study and comments on a preliminary version of this manuscript The authors would like to express their gratitude to individuals that participated in this study

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