Authors: Keliang Gao Qingxun Song Dongzhi Wei
Publish Date: 2006/02/18
Volume: 71, Issue: 6, Pages: 819-823
Abstract
Enantioselective biotransformation of dl12propanediol to d2hydroxypropanic acid was first reported by the authors In the biooxidation process there were some byproduct formed and thus influenced the ee value and output of the acid Restricting oxygen in the reaction system and offering additional proton receptor to the system displayed approving effect The latter method constructed regeneration cycle system of coenzyme In the article the bioreduction of pinacolone was coupled to the enantioselective oxidation Yield of the acid was increased by 36 and ee value of the product approached 99
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