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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0006-2952(80)90567-5

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1976-3786

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Prostaglandin ESubscript2/Subscriptmediated d

Authors: Byeong Suk Chae Tae Yong Shin Dae Keun Kim Jae Soon Eun Jae Yoon Leem Jae Heon Yang
Publish Date: 2008/05/01
Volume: 31, Issue: 4, Pages: 503-
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Abstract

Systemic lupus erythematosus SLE is characterized by inflammatory and dysregulatory immune responses including overactive B cells overproduction of proinflammatory cytokines and T cell hyperactivity PGE2 modulates a variety of immune processes at sites of inflammation including production of inflammatory cytokines However the role of PGE2 in dysregulatory inflammatory and immune responses in lupus remains unclear We investigated whether PGE2 mediates production of inflammatory cytokines in pristaneinduced lupus BALB/c mice Our results showed that levels of serum and BAL PGE2 and LPSstimulated production of PGE2 by peritoneal macrophages were remarkably increased in pristaneinduced lupus mice compared to healthy controls Exogenous PGE2 enhanced production of IL6 IL10 and NO but decreased TNFα by macrophages and augmented IFNγ IL6 and IL10 by splenocytes from pristaneinduced lupus mice compared to healthy controls Exogenous PGE2 also enhanced production of IFNγ IL6 and IL10 by thymocytes from pristaneinduced lupus mice Indomethacin Indo a PGE2 synthesis inhibitor greatly inhibited LPSinduced production of IL6 and IL10 by macrophages from pristaneinduced lupus mice while enhanced TNFα Indo remarkably inhibited Con Aincreased production of IFNγ IL6 and IL10 by splenocytes and thymocytes from pristaneinduced lupus mice Therefore our findings suggest that endogenous PGE2 may mediate dysregulation of production of proinflammatory cytokines such as IL6 IL10 and IFNγ and NO in pristaneinduced lupus mice

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