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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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1976-3786

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The relevance of polymeric synthetic membranes in

Authors: ShiowFern Ng Jennifer J Rouse Francis D Sanderson Gillian M Eccleston
Publish Date: 2012/05/03
Volume: 35, Issue: 4, Pages: 579-593
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Abstract

Synthetic membranes are composed of thin sheets of polymeric macromolecules that can control the passage of components through them Generally synthetic membranes used in drug diffusion studies have one of two functions skin simulation or quality control Synthetic membranes for skin simulation such as the siliconebased membranes polydimethylsiloxane and Carbosil are generally hydrophobic and rate limiting imitating the stratum corneum In contrast synthetic membranes for quality control such as cellulose esters and polysulfone are required to act as a support rather than a barrier These synthetic membranes also often contain pores hence they are called porous membranes The significance of Franz diffusion studies and synthetic membranes in quality control studies involves an understanding of the fundamentals of synthetic membranes This article provides a general overview of synthetic membranes including a brief background of the history and the common applications of synthetic membranes This review then explores the types of synthetic membranes the transport mechanisms across them and their relevance in choosing a synthetic membrane in Franz diffusion cell studies for formulation assessment purposes

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  2. Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic
  3. Synthesis and biological evaluation of novel fluconazole analogues bearing 1,3,4-oxadiazole moiety as potent antifungal agents
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  6. Pharmacokinetics of verproside after intravenous and oral administration in rats
  7. Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress
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  9. Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.
  10. Prostaglandin E 2 -mediated dysregulation of proinflammatory cytokine production in pristane-induced lupus mice
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  12. Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica
  13. Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
  14. Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors
  15. Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester
  16. Modulation of the genomic estrogen receptor pathway by water extracts of Cirsium japonicum
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