Journal Title
Title of Journal: Arch Pharm Res
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Abbravation: Archives of Pharmacal Research
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Publisher
Pharmaceutical Society of Korea
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Authors: Dae Hyun Kim Chan Hum Park Daeui Park Yeon Ja Choi Min Hi Park Ki Wung Chung So Ra Kim Jun Sik Lee Hae Young Chung
Publish Date: 2013/08/06
Volume: 37, Issue: 6, Pages: 813-820
Abstract
Ginsenoside Rc Rc a protopanaxadiol type ginsenoside is the active component mainly responsible for the therapeutic and pharmacologic properties of ginseng which are derived from its suppression of superoxideinduced free radicals Forkhead box O FoxO1 regulates various genes involved in cellular metabolism related to cell death and response to oxidative stress and Rc is known to prevent FoxO1 phosphorylation by activation of PI3K/Akt and subsequent inhibition of AMPactivated protein kinase AMPK in cells exposed to tertbutylhydroperoxide tBHP In the current study we attempted the mechanism of increased catalase expression by Rc through inhibition of FoxO1 activation resulting from tBHPinduced production of reactive species RS We found that overexpression of catalase induced by Rc resulted in suppression of RS production in kidney human embryo kidney 293T cells HEK293T cells and that oxidative stress induced activation of PI3K/Akt and inhibition of the AMPK pathway and FoxO1 phosphorylation leading to downregulation of catalase a FoxO1targeting gene In addition treatment of HEK293T cells with Rc resulted in cAMPresponse elementbinding protein CREBbinding protein CBP regulated FoxO1 acetylation Our results suggest that Rc modulates FoxO1 phosphorylation through activation of PI3K/Akt and inhibition of AMPK and FoxO1 acetylation through interaction with CBP and SIRT1 and that this leads to upregulation of catalase under conditions of oxidative stressA grant in 2011 from the Korea Society of Ginseng and by a grant of the Korea Healthcare Technology RD Project Ministry for Health Welfare Family Affairs Republic of Korea A090582 and this work was carried out with the support of “Cooperative Research Program for Agriculture Science and Technology Development Project No PJ006522132013” Rural Development Administration Republic of Korea This work was also supported by the RD Program of MKE/KEIT 10040391 Development of Functional Food Materials and Device for prevention of Agingassociated Muscle Function Decrease We also take this opportunity to thank the Aging Tissue Bank Busan Korea for supplying research materials
Keywords:
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