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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0046-8177(95)90093-4

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1976-3786

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Emphasis Type="Italic"In vivo/Emphasis electro

Authors: Jin Yi Han Jin Tae Hong KiWan Oh
Publish Date: 2010/10/09
Volume: 33, Issue: 9, Pages: 1293-1299
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Abstract

Reactive oxygen species are regarded as important factors in the initiation and progression of many diseases Therefore measurement of redox status would be helpful in understanding the “Redox Navigation” of such diseases Because electron spin resonance ESR shows good signal responses to nitroxyl radical and various redoxrelated species such as oxygen radicals and antioxidants the in vivo ESR/nitroxyl probe technique can provide useful information on realtime redox status in a living body ESR spectrometers for in vivo measurements can be operated at lower frequencies approximately 35 GHz 1 GHz 700 MHz and 300 MHz than usual 9–10 GHz Several types of resonators were also designed to minimize the dielectric loss of electromagnetic waves caused by water in animal bodies In vivo ESR spectroscopy and its imaging have been used to analyze radical generation redox status partial pressure of oxygen and other conditions in various diseases In addition ESR has been used to analyze injury models related to oxidative stresses such as nitroxyl radicals The application of in vivo ESR for diseases related to oxidative injuries currently being investigated and the accumulation of basic data for therapy is ongoing Recent progress in the instrumentation for in vivo ESR spectroscopy and its application to the life sciences are reviewed because measurement of redox status in vivo is considered necessary to understand the initiation and progression of diseases

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