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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/bf02977514

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ISSN

1976-3786

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Optimization of ultrasonicassisted extraction of

Authors: Hyo Seon Kim A Yeong Lee Ji Eun Jo Byeong Cheol Moon Yunui Ji Ho Kyoung Kim
Publish Date: 2013/11/30
Volume: 37, Issue: 11, Pages: 1437-1444
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Abstract

In order to optimize the extraction conditions of continentalic acid the main compound from Aralia continentalis root we developed a model using the response surface methodology The continentalic acid yield was analyzed and quantified by highperformance liquid chromatography coupled with UV detection The extraction solvent temperature and time the three main factors for ultrasoundassisted extraction were optimized using the central composite design Analysis of variance showed a good model fit R 2 = 09323 The maximum extraction of continentalic acid obtained experimentally was 10138  under an extraction temperature of 33 °C and extraction time of 28 min when 100  ethanol was used as the solvent The experimental value was in good agreement the yield 10103  with those predicted values The results clearly showed that quality by statistical design could be effectively applied to optimize extraction of continentalic acid

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