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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0305-4179(90)90204-A

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1976-3786

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Developing Emphasis Type="Italic"Streptomyces ve

Authors: Eun Ji Kim Inho Yang Yeo Joon Yoon
Publish Date: 2015/07/28
Volume: 38, Issue: 9, Pages: 1606-1616
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Abstract

The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages such as rapid growth rate convenient genetic manipulation and an abundant supply of common biosynthetic building blocks In recent decades several S venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products In this review article we have provided a schematic look at these host strains which were used to synthesize natural products from genetically engineered biosynthetic gene clustersResearch in authors’ laboratory has been supported by the National Research Foundation of Korea NRF funded by the Ministry of Science ICT and Future Planning MISP 2013R1A2A1A01014230 the Intelligent Synthetic Biology Center of the Global Frontier Project funded by MISP 20110031961 High Valueadded Food Technology Development Program Ministry of Agriculture Food and Rural Affairs Republic of Korea and the National Research Council of Science and Technology through the Degree Research Center program DRC143KBSI

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