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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/bf00516815

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1976-3786

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Antiinflammatory properties of samidin from Emph

Authors: Salman Khan Omer Shehzad Kyoung Jin Lee Alev Tosun Yeong Shik Kim
Publish Date: 2014/03/24
Volume: 37, Issue: 11, Pages: 1496-1503
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Abstract

Seseli is a herb widely used for its antiinflammation antiflatulence and various other healing properties In the present study we investigated the effects of samidin on the production of proinflammatory mediators in lipopolysaccharide LPSstimulated RAW 2647 cells The results demonstrated that samidin significantly inhibited the production of nitric oxide as well as the gene expression levels of inducible nitric oxide synthase and cyclooxygenase2 The results from an electrophoretic mobility shift assay illustrated that samidin significantly suppressed NFκB and AP1 DNAbinding affinity In addition both the NFκB subunit p65 and the AP1related cjun were markedly inhibited by samidin The time course experiment demonstrated that samidin showed significant inhibitory effect on p38 and JNK activation Furthermore tumor necrosis factorα mRNA level were remarkably downregulated by samidin in LPSstimulated macrophages based on quantitativerealtime polymerase chain reaction Our results suggested that samidin has a potential to be developed as a therapeutic agent for various inflammatory diseases

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