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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0146-664x(81)90104-0

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1976-3786

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Lipoxygenase inhibitors from the latex of Emphasi

Authors: Wael M AbdelMageed Nadia H Mohamed Miaomiao Liu Ali A ElGamal Omer A Basudan Mady Ahmed Ismail Ronald J Quinn Xueting Liu Lixin Zhang Ahmed A M Shoreit
Publish Date: 2016/03/09
Volume: , Issue: , Pages: 1-9
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Abstract

A radicalscavenging guided phytochemical study of the latex of Calotropis Procera afforded five lignans 1–5 including a new one 4 The structural determination was accomplished using 1D and 2DNMR highresolution electrospray ionization mass spectrometry HRESIMS and correlation with known compounds Among the isolated compounds acylated lignans 3–5 showed stronger antioxidant activity than nonacylated derivatives 12 Antiinflammatory activity was evaluated by determining the inhibitory potential against 5 and 15lipoxygenase enzymes The highest antiinflammatory activity was observed in compound 4 with IC50s values of 76 µM and 27 µM against 5LOX and 15LOX respectively

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