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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0960-1481(94)90265-8

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1976-3786

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Effect of sodium carboxymethylcellulose and fucidi

Authors: SooJeong Lim Jeong Hoon Lee Ming Guan Piao MiKyung Lee Dong Hoon Oh Du Hyung Hwang Qi Zhe Quan Chul Soon Yong HanGon Choi
Publish Date: 2010/07/27
Volume: 33, Issue: 7, Pages: 1073-1081
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Abstract

The purpose of this study was to investigate the effect of sodium carboxymethylcellulose NaCMC and fucidic acid on the gel characterization for the development of sodium fucidateloaded wound dressing The crosslinked hydrogel films were prepared with polyvinyl alcohol PVA and sodium carboxymethylcellulose NaCMC using the freezethawing method Their gel properties such as gel fraction swelling water vapor transmission test morphology tensile strength and thermal property were investigated In vitro protein adsorption test and release were performed NaCMC decreased the gel fraction and tensile strength of the hydrogels but increased the swelling ability water vapor transmission rate elasticity and porosity of hydrogels Thus the wound dressing developed with PVA and NaCMC was more swellable flexible and elastic than that with only PVA because of its crosslinking interaction with PVA However the drug had a negative effect on the gel properties of hydrogels but there were no significant differences In particular the hydrogel composed of 25 PVA 1125 NaCMC and 02 drug might give an adequate level of moisture and build up the exudates on the wound area Thus this sodium fucidateloaded hydrogel could be a potential candidate for wound dressing with excellent forming

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