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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/978-1-4302-0759-7_17

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1976-3786

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Antioxidant activity of 345trihydroxyphenylacet

Authors: Jina Kim Victor Sukbong Hong Jinho Lee
Publish Date: 2013/07/01
Volume: 37, Issue: 3, Pages: 324-331
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Abstract

A series of amide derivatives of 345trihydroxyphenylacetic acid was synthesized in two steps The antioxidant activities were evaluated by using four different in vitro models such as ABTS and DPPH radical scavenging activity and FTC and TBA antilipid peroxidation activity Most of compounds were more powerful radical scavengers than vitamin C and were comparable to Trolox It was found that there were no direct correlations between radical scavenging and antiperoxidation activities The inhibitory activity of compound on lipid peroxidation showed remarkable dependency on both the number of phenolic hydroxyl group and the length of methylene linker in Narylalkyl group of amide Compound 14 a conjugate of 345trihydroxyphenylacetic acid and dopamine was found as powerful antioxidant as propyl gallate in all four antioxidant assays

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