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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Publisher

Pharmaceutical Society of Korea

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DOI

10.1002/wilm.10511

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ISSN

1976-3786

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Synthesis characterization and biological activit

Authors: M Saeed Arayne Najma Sultana Urooj Haroon M Hashim Zuberi Syeda Bushra Shakeb Rizvi
Publish Date: 2010/12/30
Volume: 33, Issue: 12, Pages: 1901-1909
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Abstract

The present study was designed to help develop new agents with better antimicrobial profiles Specifically we focused on modification of the basic structure of ofloxacin by introducing new functionality at its C3 position For this purpose the carboxylic group at the C3 position of ofloxacin was replaced by an amide group through an ester aminolysis reaction The structure of these derivatives was established by various analytical techniques ie IR 1HNMR 13CNMR CHNS elemental analysis and mass spectrometry The antibacterial activity of ofloxacin and its derivatives against ten different Grampositive and Gramnegative microorganisms was studied using a disk susceptibility method These compounds were further tested for their activity against various fungi and compared to ofloxacin The synthesized compounds showed diverse antimicrobial profiles Among them a few compounds possessed a comparable or better activity in comparison to the reference drug

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  2. Causal effects of synthetic chemicals on mitochondrial deficits and diabetes pandemic
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  13. Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
  14. The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study
  15. Synthesis of 2-alkynyl substituted 4′-thioadenosine derivatives and their binding affinities at the adenosine receptors
  16. Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester
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