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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1016/0167-5087(84)90392-2

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ISSN

1976-3786

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Phenolic compounds with IL6 inhibitory activity f

Authors: A Ryun Kim Qinglong Jin HongGuang Jin Hae Ju Ko EunRhan Woo
Publish Date: 2013/09/08
Volume: 37, Issue: 7, Pages: 845-851
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Abstract

A new biflavonoid named asteryomenin 1 as well as six known phenolic compounds esculetin 2 4Oβdglucopyranoside3hydroxy methyl benzoate 3 caffeic acid 4 isoquercitrin 5 isorhamnetin3Oglucoside 6 and apigenin 7 were isolated from the aerial parts of Aster yomena The structures of compounds 1–7 were identified based on 1D and 2D NMR including 1H–1H COSY HSQC HMBC and NOESY spectroscopic analyses Compounds 2–7 were isolated from this plant for the first time For these isolates the inhibitory activity of IL6 production in the TNFα stimulated MG63 cell was examined Among these isolates compounds 4 and 7 appeared to have potent inhibitory activity of IL6 production in the TNFα stimulated MG63 cell while compounds 1–3 and 5–6 showed moderate activity

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