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Title of Journal: Arch Pharm Res

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Abbravation: Archives of Pharmacal Research

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Pharmaceutical Society of Korea

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DOI

10.1007/bf01576380

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1976-3786

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The effective mechanism of the polysaccharides fro

Authors: Jia Wang Chengxin Sun Yan Zheng Hongling Pan Yifa Zhou Yuying Fan
Publish Date: 2013/08/21
Volume: 37, Issue: 4, Pages: 530-538
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Abstract

Ginseng acidic polysaccharide WGPA isolated from the root of Panax ginseng C A Meyer was fractionated into WGPAA and WGPAN by anionexchange chromatography The antifatigue activity of ginseng acidic polysaccharide WGPA has been reported in our previous research This present study was designed to identify its active component and elucidate the mechanism for preventing chronic fatigue syndrome CFS WGPA WGPAA and WGPAN were orally administered to mice once daily for 15 days The effects of these compounds on physiological biomarkers of oxidative stress and on the morphology of the mitochondria in striated skeletal muscle were assessed The results of forced swimming testinduced indicated that WGPA and WGPAA could lengthen the swimming time while WGPAN could not In addition malondialdehyde and lactate dehydrogenase levels in serum were enhanced while those of superoxide dismutase and glutathione peroxidase were lowered Interestingly the structural degeneration of mitochondria were all ameliorated These findings suggested that WGPAA is the active component of WGPA it might have potential therapeutic effects for CFS and the oxidative stress might be involved in the pathogenesis Our results also provided essential data for a better understanding of the antifatigue effects of P ginseng extractsThe authors would like to thank Mrs Shlomit FlaisherGrinberg and Mr Jeff Iteku B for helpful discussions and revise with the manuscript This work was supported by the Chinese New Drug Creation and Manufacturing Program 2012ZX09502001001 the Doctoral Fund of Ministry of Education of China 20110043120009 the Natural Science Foundation of Jilin Province No 201101013 and the Fundamental Research Funds for the Central Universities 12SSXM005

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